Basic Information
VIS ID
TVIS44015405
Fusion event
HTLV-1-RYR3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
34084755/33792554 (Hg38)
End
34084755/33792554 (Hg38)
Orient
+
Location type
Intronic
Target gene
RYR3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-367-5p
Nearest miRNA
hsa-mir-1268a/Upstream/2727413; hsa-mir-10393/Downstream/589515;
Nearest TSS
ENST00000557528/Upstream/35016; ENST00000637201/Downstream/18107;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/480752, chr15-CpG: 114/Downstream/245814
Upstream sequence
CCCATCAGTCAGTCCCCTGGGGTGGTGGCCATATGCTGTGCTGGACAGGCTGTGTGTCCCAGTTCACCATCATCGCTTCTATTCTACAGAACTTCAAAGG
Downstream sequence
TTGAAAGTCTCTAATGTCATAATTAGGCAAATTAATTCATGTCATAGGAGAAATTTTTAATGTAATTCACTCTTTCCCCAATGTTCGTTTGGTGCACAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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