Basic Information
VIS ID
TVIS44015424
Fusion event
HTLV-1-ATMIN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
81079747/81046142 (Hg38)
End
81079747/81046142 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA16D
Target gene
ATMIN
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-744-5p ; hsa-mir-425-3p ; hsa-mir-19a-3p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-518a-5p ; hsa-mir-519a-3p ; hsa-mir-527 ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548l ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-3973 ; hsa-mir-510-3p ; hsa-mir-411-5p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-7847-3p ; hsa-mir-4657 ; hsa-mir-4491
Nearest miRNA
hsa-mir-1225/Upstream/4177123; hsa-mir-11401/Downstream/338876;
Nearest TSS
ENST00000527434/Upstream/5617; ENST00000562450/Downstream/9159;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/9584, chr16-CpG: 64/Downstream/30738
Nearest cancer related gene
ATMIN(TSG, No orient, 0)
Upstream sequence
ATCCAAACCTTGGGAACAGGGAGTTATGGAAACATGCCTATGACTTCATCTTGGGGTGTGTCCTATGAAGATCCTTTCTGGTCTCCACAGTAGGCCAGAG
Downstream sequence
TTGGGGGCTCTGGAGCTGTTTCCCCAAGTGCATCCACAAGCTGGATCTGAGTTTTGTCACTCTAAAATTAAACAAGAAAAAAAGTGGGAAAAGGGCATCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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