Basic Information
VIS ID
TVIS44015433
Fusion event
HTLV-1-EIF2AK3-DT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
88927908/88628390 (Hg38)
End
88927908/88628390 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
EIF2AK3-DT
Nearest miRNA
hsa-mir-1285-2/Upstream/545791; hsa-mir-10b/Downstream/183980;
Nearest TSS
ENST00000437798/Upstream/219; ENST00000283646/Downstream/63254;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/613, chr2-CpG: 65/Downstream/63061
Nearby gene
EIF2AK3(-814) ;
Upstream sequence
cacgctttgtacctcaccaAAGACAGTGATGAAATTGCAAAAGGGCAGAGTGGAGAAGACTGGAATGTTCAGCCAAGGCATTTGAACTTTTAATGCTGCA
Downstream sequence
AGTCAAGACTTCCTGAAGATTTTTGAGCAGATGAGTGAAGTGATAAGAAAATGCATCTTCAGCAGTGACAGCATCAACGAGGAGGAGACTGGCCGGGAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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