Basic Information
VIS ID
TVIS44015456
Fusion event
HTLV-1-OTOP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
4221074/4219347 (Hg38)
End
4221074/4219347 (Hg38)
Orient
-
Location type
Intronic
Target gene
OTOP1
Nearest miRNA
hsa-mir-4800/Upstream/1969191; hsa-mir-12113/Downstream/1703928;
Nearest TSS
ENST00000502981/Upstream/452949; ENST00000502918/Downstream/7542;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/75407, chr4-CpG: 138/Downstream/7025
Upstream sequence
cttttaacaaagtaataaaggtttaaaataaagtagtgaacaaagaggaatgcaacaaaaagaaagtcagaatggcaatattaatatcagaccgtatggg
Downstream sequence
atttaaagttaatgtaataagtaggataaagaATCCTTCCTCCTTTATCGCTACATATGATAAAAGACAGATTgccgggcgcggtggctcacgcctgtaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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