VISDB - VIS Detail

Basic Information

VIS ID

TVIS44015458

Fusion event

HTLV-1-ANKRD33B integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr5

Cytoband

p15.2

Reference genome

GRCh37/hg19

Start

10630577/10630465 (Hg38)

End

10630577/10630465 (Hg38)

Orient

Location type

Intronic

Target gene

ANKRD33B

miRNAs that regulate target gene

hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-142-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-448 ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-5590-3p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-429 ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-670-5p ; hsa-mir-3154 ; hsa-mir-4319 ; hsa-mir-4324 ; hsa-mir-4251 ; hsa-mir-6770-5p ; hsa-mir-18a-3p ; hsa-mir-874-3p ; hsa-mir-3173-5p ; hsa-mir-6752-3p ; hsa-mir-6799-3p ; hsa-mir-542-3p ; hsa-mir-4501 ; hsa-mir-190a-3p ; hsa-mir-605-5p ; hsa-mir-5011-5p ; hsa-mir-6083 ; hsa-mir-4709-3p ; hsa-mir-7704 ; hsa-mir-3179 ; hsa-mir-4526 ; hsa-mir-1250-5p ; hsa-mir-3660 ; hsa-mir-125a-3p ; hsa-mir-888-3p ; hsa-mir-552-3p ; hsa-mir-3936 ; hsa-mir-4504 ; hsa-mir-4724-5p ; hsa-mir-8084 ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-146b-3p ; hsa-mir-7976 ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-504-5p ; hsa-mir-4275 ; hsa-mir-205-3p ; hsa-mir-1253 ; hsa-mir-4732-3p ; hsa-mir-345-3p ; hsa-mir-410-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-3677-3p ; hsa-mir-6742-5p ; hsa-mir-193b-5p

Nearest miRNA

hsa-mir-10397/Upstream/152320; hsa-mir-103a-1/Downstream/4195464;

Nearest TSS

ENST00000502646/Upstream/2240; ENST00000606588/Downstream/130600;

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/64897, chr5-CpG: 218/Downstream/8418

Upstream sequence

CAAACATGCATGAAAGTCTGGATaagtacatttcaaccttctgcttccatcacgcctgcaaacatcccatcggccaaggTTCCACTAGACAGAGAACTGG

Downstream sequence

GAAGTCACTTAACAAAGGGCAGTGTGAAGAAGATGGGCCATTAGTGCATTGTAGGAACTAAGggccttctgaaggttcactaaaatcaacttgcaaaagg

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.