Basic Information
VIS ID
TVIS44015482
Fusion event
HTLV-1-PKP4-AS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
159580358/158723846 (Hg38)
End
159580358/158723846 (Hg38)
Orient
-
Location type
Intronic
Target gene
PKP4-AS1
Nearest miRNA
hsa-mir-128-1/Upstream/7355435; hsa-mir-10b/Downstream/462989;
Nearest TSS
ENST00000437798/Upstream/37943; ENST00000309950/Downstream/134;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/265545, chr2-CpG: 146/Downstream/244496
Nearby gene
PKP4(+42418) ;
Upstream sequence
CCAGAAAGGAGGGAATCTACCCTTGTATAAGTGCCATTGCATGCCAACCTCTGCCCTCCCATCACAGGTGAGGGGTTGATGCCCTATAAAAATGCACTAT
Downstream sequence
CACTCTGCCCAAGGCCTCAGTGAATTTGTCCCAAATGAACCTTCTCCCCTCAGTACCAAACCTACCGCCCTGACCTGCTATCTCTGGTTCCAGCTCTGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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