Basic Information
VIS ID
TVIS44015490
Fusion event
HTLV-1-IPPK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
95397279/92634997 (Hg38)
End
95397279/92634997 (Hg38)
Orient
-
Location type
Intronic
Target gene
IPPK
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-382-3p ; hsa-mir-3163 ; hsa-mir-3662 ; hsa-mir-4460 ; hsa-mir-3591-5p ; hsa-mir-4727-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-139-5p ; hsa-mir-1296-3p ; hsa-mir-4773 ; hsa-mir-3120-3p ; hsa-mir-3133 ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-6838-5p ; hsa-mir-15a-5p ; hsa-mir-497-5p ; hsa-mir-7855-5p ; hsa-mir-7973 ; hsa-mir-589-5p ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-9-5p ; hsa-mir-6793-3p ; hsa-mir-627-5p ; hsa-mir-924 ; hsa-mir-4725-5p ; hsa-mir-211-3p ; hsa-mir-3065-3p ; hsa-mir-1306-5p ; hsa-mir-140-3p ; hsa-mir-125b-5p ; hsa-mir-4319 ; hsa-mir-125a-5p
Nearest miRNA
hsa-mir-101-2/Upstream/106939; hsa-let-7a-1/Downstream/959844;
Nearest TSS
ENST00000422679/Upstream/14667; ENST00000494669/Downstream/3082;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/308673, chr9-CpG: 89/Downstream/34533
Upstream sequence
GCTCAGCCCCATCTTGGGGTTTCGAATTAGCAAGGTCACAGACGTGCTTTCTTTTCTAGAAACAAGTGACCCTGTTCCTCCTTTACAAGGCACTACATTC
Downstream sequence
CAGAGCAGGCCTGGGCACCTGGGAGCGGAGGACTGGGGTAGGAAGTGGCCGGCATGCTTCATCCTCCTGGGAAGCTGTGCCTTGGGAGGCGCATTCTTAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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