Basic Information
VIS ID
TVIS44015493
Fusion event
HTLV-1-SARS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
109756890/109214268 (Hg38)
End
109756890/109214268 (Hg38)
Orient
-
Location type
Intronic
Target gene
SARS
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-29a-3p ; hsa-mir-26a-5p ; hsa-mir-1207-5p ; hsa-mir-1237-5p ; hsa-mir-1245b-3p ; hsa-mir-1909-3p ; hsa-mir-4488 ; hsa-mir-4506 ; hsa-mir-4525 ; hsa-mir-4697-5p ; hsa-mir-4716-3p ; hsa-mir-4763-3p ; hsa-mir-4790-3p ; hsa-mir-486-3p ; hsa-mir-5010-5p ; hsa-mir-5187-5p ; hsa-mir-636 ; hsa-mir-6721-5p ; hsa-mir-6722-3p ; hsa-mir-6741-5p ; hsa-mir-6794-5p ; hsa-mir-6798-5p ; hsa-mir-6846-5p ; hsa-mir-6848-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1316964; hsa-mir-11399/Downstream/384625;
Nearest TSS
ENST00000473358/Upstream/286; ENST00000471705/Downstream/16890;
Nearest CpG islands
chr1-CpG: 55/Target, None/Upstream, None/Downstream
Upstream sequence
CCCAATTTTCTCTCTCAAATCCAGCCACCGCTCCTGAGGCCACAGCTTCCACCCTTCGTCAGACCCCCTCCCAGGGTGCGGTGGCTCCGAGGTTCTCCCC
Downstream sequence
ATCCCCGAAAACACAGCCTGGTCGCCGGGGTCATCCCACTTTCTCCTCCACCCGGGCGGAGCGAGGTCCCTTCCACGCGTGCTCAGTGCCGTTCGCTGCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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