Basic Information
VIS ID
TVIS44015495
Fusion event
HTLV-1-NPAS4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
66188463/66420992 (Hg38)
End
66188463/66420992 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
NPAS4
miRNAs that regulate target gene
hsa-mir-146b-3p
Nearest miRNA
hsa-mir-10392/Upstream/771739; hsa-let-7a-2/Downstream/513442;
Nearest TSS
ENST00000527297/Upstream/48778; ENST00000639555/Downstream/12;
Nearest CpG islands
chr11-CpG: 88/Target, None/Upstream, None/Downstream
Nearby gene
NPAS4(+12) ;
Upstream sequence
GGAGGAGGAGCCCCCCTCCCCAGTCAGCGGCTCCCGCTGCAGCTTGCTTAGCCCAGCCTCCCGCTCTCCCGCCCCCCCGGCTCTAAAACGAGCCCCCCAC
Downstream sequence
GCCTGGCAGGAGCTATATAAGGCGGCGTGAGGCAGGCGAGGGGGGCAGCGCAGCCGAGCGGAGCCCAGGAGAGCAGAGAGCGAGCCTGAGCGAGAGACGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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