Basic Information
VIS ID
TVIS44015504
Fusion event
HTLV-1-SORBS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
186853891/185932737 (Hg38)
End
186853891/185932737 (Hg38)
Orient
-
Location type
Intronic
Target gene
SORBS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1226-3p ; hsa-mir-129-5p ; hsa-mir-3152-5p ; hsa-mir-4774-3p ; hsa-mir-6836-3p ; hsa-mir-3671 ; hsa-mir-139-3p ; hsa-mir-372-5p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-660-3p
Nearest miRNA
hsa-mir-12113/Upstream/994297;
Nearest TSS
ENST00000502981/Upstream/14597; ENST00000508051/Downstream/633;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/293530, chr4-CpG: 123/Downstream/171841
Upstream sequence
GTCACTGCATTGCAGGGCTGTATTTGTTGGCAAGCATCTGAGACCAGCCTCTGCAAACTGCTGTAGGCAGGGCCTGGCCTAAAGCGGATGAGCCCCCCTG
Downstream sequence
GGGCTCGGTTGCCCTGGCCACACCATGATCCTTCTCTATGACTTACcctctgaagaaaacacagcttttcctagcagctaaaaaacagtttctctagact
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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