VISDB - VIS Detail

Basic Information

VIS ID

TVIS44015509

Fusion event

HTLV-1-CDC14A integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

29186194

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

p21.2

Reference genome

GRCh37/hg19

Start

100884706/100419150 (Hg38)

End

100884706/100419150 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA1E

Target gene

CDC14A

miRNAs that regulate target gene

hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-628-3p ; hsa-mir-630 ; hsa-mir-301a-3p

Nearest miRNA

hsa-mir-101-1/Upstream/137842; hsa-mir-11399/Downstream/7478073;

Nearest TSS

ENST00000473358/Upstream/55989; ENST00000469387/Downstream/4582;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/65807, chr1-CpG: 146/Downstream/119862

Upstream sequence

tggtgtgtacctgtagtcctagctacttgggaggctgaggtgggaggatggcttgagccttgggggtggaggttgtagtgagctgagattgtgccactgc

Downstream sequence

actccagcctgtgtgacagagccagaacctgtctaaaataaaataaataaaaaGAGAGAGACTGACTGTGACTGTGAAGAGATAATCAGTCTGGGTATTG

Reference

Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.