Basic Information
VIS ID
TVIS44015514
Fusion event
HTLV-1-CASZ1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
10795606/10735549 (Hg38)
End
10795606/10735549 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
CASZ1
miRNAs that regulate target gene
hsa-mir-151a-5p ; hsa-mir-4665-3p ; hsa-mir-486-3p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-885-3p ; hsa-mir-4706 ; hsa-mir-4749-5p ; hsa-mir-3195 ; hsa-mir-3648 ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-6775-5p ; hsa-mir-5090 ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-1908-3p ; hsa-mir-6784-5p ; hsa-mir-7975 ; hsa-mir-4540 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4670-3p ; hsa-mir-648 ; hsa-mir-6838-3p ; hsa-mir-4517 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-8068 ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-33a-3p
Nearest miRNA
hsa-mir-12136/Upstream/768091; hsa-mir-101-1/Downstream/1293609;
Nearest TSS
ENST00000473358/Upstream/29974; ENST00000613864/Downstream/61099;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/30681, chr1-CpG: 244/Downstream/58288
Upstream sequence
CCCTCTGCTCCCGCTGCCACTTGCAGGCTCAGCCAGCTCCACGCAGCGCCAGGGCTGTCCCCAAAGTTTGGATCAAACTTTGCCTGGGGGAGGGGGTGTG
Downstream sequence
CTGCAGGAAGGAGGGATGGCTGGTGCCTCTTAGCCAAGTGCCACGGACAGAAGTTTTGCCTTTACCCATCCCAAATGACTCTCCCGGTTTCTGTGCCCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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