VISDB Viral Integration Site DataBase

VIS ID

TVIS44015516

Fusion event

HTLV-1-VAV3 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr1

Cytoband

p13.3

Reference genome

Start

End

108499745/107957123 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-186-5p ; hsa-mir-98-5p ; hsa-mir-149-5p ; hsa-mir-27a-5p ; hsa-mir-4290 ; hsa-mir-378g ; hsa-mir-939-3p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4667-3p ; hsa-mir-6779-3p ; hsa-mir-28-3p ; hsa-mir-4432 ; hsa-mir-185-3p ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-6787-5p ; hsa-mir-4492 ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-4508 ; hsa-mir-5089-3p ; hsa-mir-500a-3p ; hsa-mir-760 ; hsa-mir-8072 ; hsa-mir-3194-3p ; hsa-mir-6804-3p ; hsa-mir-3960 ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-4793-3p ; hsa-mir-3130-3p ; hsa-mir-6741-3p ; hsa-mir-455-5p ; hsa-mir-6079 ; hsa-mir-6763-3p ; hsa-mir-513b-5p ; hsa-mir-6789-3p ; hsa-mir-671-5p ; hsa-mir-6828-5p ; hsa-mir-2115-5p ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-6799-3p ; hsa-mir-3173-5p ; hsa-mir-6846-3p ; hsa-mir-7706 ; hsa-mir-4680-5p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-4315 ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6784-5p ; hsa-mir-6752-3p ; hsa-mir-4532 ; hsa-mir-5587-3p ; hsa-mir-4707-5p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7113-5p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-125b-2-3p ; hsa-mir-4457 ; hsa-mir-525-3p ; hsa-mir-524-3p ; hsa-mir-4428 ; hsa-mir-4511 ; hsa-mir-3133 ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-4665-3p ; hsa-mir-4436b-5p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-7114-3p ; hsa-mir-1180-5p ; hsa-mir-3664-3p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-5088-3p ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-4717-3p ; hsa-mir-4802-3p ; hsa-mir-4435 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-6743-3p ; hsa-mir-3670 ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-4733-3p ; hsa-mir-1226-3p ; hsa-mir-4482-3p ; hsa-mir-4670-3p ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-138-2-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-2117 ; hsa-mir-130b-5p ; hsa-mir-148a-5p ; hsa-mir-3912-5p ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-1226-5p ; hsa-mir-6771-5p ; hsa-mir-425-3p ; hsa-mir-6084 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-4529-5p ; hsa-mir-196a-3p ; hsa-mir-7160-5p ; hsa-mir-214-5p ; hsa-mir-4721 ; hsa-mir-3616-3p ; hsa-mir-4539 ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6078 ; hsa-mir-6748-3p ; hsa-mir-6832-3p ; hsa-mir-6785-3p ; hsa-mir-6733-3p ; hsa-mir-892c-5p ; hsa-mir-15a-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3127-5p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-6798-5p ; hsa-mir-1250-3p ; hsa-mir-6783-5p ; hsa-mir-3178 ; hsa-mir-4634 ; hsa-mir-6499-5p ; hsa-mir-6892-3p ; hsa-mir-6840-5p ; hsa-mir-6865-3p ; hsa-mir-6856-3p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-34a-5p ; hsa-mir-6499-3p ; hsa-mir-498 ; hsa-mir-561-5p ; hsa-mir-499a-5p

Nearest miRNA

hsa-mir-101-1/Upstream/59819; hsa-mir-11399/Downstream/1641770;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/476303, chr1-CpG: 97/Downstream/7506

Nearest cancer related gene

VAV3(OG, No orient, 0)

Upstream sequence

aaacccaaaagaaaggggtattaagagagtgggatgcatgaaactgagaagagagagggtaactggtaataacTTCCAACTCAGAGTCCAAGACAGAATG

Downstream sequence

TGTTCCCTTTCTCACTAAAATGTGCCCCTTCTTTATGACACTTCTGTCACCTGATGCTGAAACCTGGGTCTCAACCTAGATACTTTCCACTCTTTCTCTG