Basic Information
VIS ID
TVIS44015537
Fusion event
HTLV-1-KAZN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
GRCh37/hg19
Start
15055922/14729426 (Hg38)
End
15055922/14729426 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
KAZN
Nearest miRNA
hsa-mir-12136/Upstream/2150403; hsa-mir-101-1/Downstream/2129523;
Nearest TSS
ENST00000473358/Upstream/130709; ENST00000376028/Downstream/194704;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/129929, chr1-CpG: 21/Downstream/71661
Upstream sequence
TTTATCCAAGACGTGCACCTGGGAGCAGTCAGCTCTGCAGAGCCCCTCGCTATCTTCTCACCCAGAATAGCCGGGCTTTCTTCCCTCCCACACTAATTGG
Downstream sequence
TTCCATTCGATGCTTTTATAGGCGACCCTAATGGGTTTTGTGAGATGTCGTATTAAGTCTGTGGTCCATAGAGTAATGCCCTTCGCTGTCAGGGAATGCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate