Basic Information
VIS ID
TVIS44015542
Fusion event
HTLV-1-PI4KB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
151277760/151305284 (Hg38)
End
151277760/151305284 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
PI4KB
miRNAs that regulate target gene
hsa-mir-191-5p ; hsa-mir-877-3p ; hsa-mir-331-3p ; hsa-mir-23b-3p ; hsa-mir-18a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/753270; hsa-mir-1182/Downstream/240512;
Nearest TSS
ENST00000473358/Upstream/3418; ENST00000609583/Downstream/1149;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/21991, chr1-CpG: 21/Downstream/22762
Upstream sequence
cgaaatcctgacttcaagcgatccacccacctcggcctcccaaagtgttgggattacaggtgtgagccactgcgcctggccAGCTGTGTTAATAGctcta
Downstream sequence
cacaaaattctgctctggctcttcatgccccagaataaagttcaagtttctttccccagcttacagggtccttcctatagtctggtccatgcccacgtgt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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