Basic Information
VIS ID
TVIS44015543
Fusion event
HTLV-1-S100A7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
153431447/153458971 (Hg38)
End
153431447/153458971 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA1F
Target gene
S100A7
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1913080; hsa-mir-1182/Downstream/230734;
Nearest TSS
ENST00000473358/Upstream/19022; ENST00000420695/Downstream/903;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/197134, chr1-CpG: 40/Downstream/76977
Nearest cancer related gene
S100A7(OG, No orient, 0)
Upstream sequence
CACAGGCACTAAGGAAGTTGGGGAAGTTCTCCTTCATCATCGTCAGCAGGCTTGGCTTCTCAATCTTGTCATCACGTCTGGTGTATTTGTGAAACATGTC
Downstream sequence
GATCATGCCTATTATGGACCTCTCAGCTTGAGTGTTGCTCATCTTTGCTTTCAAAAAGCCTTCAGGAAATAAAGACAATCATTTTTTTCCCTTCATTTAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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