Basic Information
VIS ID
TVIS44015551
Fusion event
HTLV-1-FBXO42 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
16596745/16270250 (Hg38)
End
16596745/16270250 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
FBXO42
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-1281 ; hsa-mir-6881-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-627-3p ; hsa-mir-877-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p
Nearest miRNA
hsa-mir-12136/Upstream/3691227; hsa-mir-101-1/Downstream/588699;
Nearest TSS
ENST00000473358/Upstream/16657; ENST00000475078/Downstream/45117;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/32946, chr1-CpG: 52/Downstream/81829
Upstream sequence
cagccActttctcttcttataaagccaccagtccccactcccagtctaacccattaatccaggaacgaattaatccattctgctgtcatgacccaaacac
Downstream sequence
ctcttaaagaccccacctctcaatactgctacactggggattaactttcaacacatgtttcagagggaacaaacattcaaaccatggcaAGCCCCATCAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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