Basic Information
VIS ID
TVIS44015561
Fusion event
HTLV-1-DNM3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
172326154/172357014 (Hg38)
End
172326154/172357014 (Hg38)
Orient
-
Location type
Intronic
Target gene
DNM3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/212370; hsa-mir-1182/Downstream/3611356;
Nearest TSS
ENST00000473358/Upstream/212220; ENST00000491124/Downstream/22004;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/514829, chr1-CpG: 35/Downstream/86713
Upstream sequence
aaaaccttatggggatatatgtgaaaaagatacaagaggcaaattacaggaggctcccaatgactaaatctgggacaatttcagaaataaaataatgaca
Downstream sequence
gtaatggattataatccatagaataaaataagaatccatacttacataaataaacagttgaatgagtaattatatgaaggagaagggaaagctgttcctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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