Basic Information
VIS ID
TVIS44015566
Fusion event
HTLV-1-ASTN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
177095353/177126217 (Hg38)
End
177095353/177126217 (Hg38)
Orient
+
Location type
Intronic
Target gene
ASTN1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1273e ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-3915 ; hsa-mir-1200 ; hsa-mir-7162-5p ; hsa-mir-378a-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-6804-5p ; hsa-mir-3928-3p ; hsa-mir-544b ; hsa-mir-4324
Nearest miRNA
hsa-mir-101-1/Upstream/96772; hsa-mir-1182/Downstream/1551532;
Nearest TSS
ENST00000473358/Upstream/93667; ENST00000460161/Downstream/38466;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/918542, chr1-CpG: 44/Downstream/38039
Upstream sequence
TTCTTGGCTCATTCCTTGCTGTCAGTGCTTTTATTTTATCATCACCATCATCATCATTATCCtatcagatatatcttaggaccatcatctgattgccttg
Downstream sequence
ggcttcccacctctgagaccctcagctgcttgctccattttagctgccCTTAGTAACTGATGAAGTTGACCTGAGCCAGCATGGCTTTGCTGCTTAGGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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