Basic Information
VIS ID
TVIS44015572
Fusion event
HTLV-1-CACNA1E integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
181767215/181798079 (Hg38)
End
181767215/181798079 (Hg38)
Orient
-
Location type
Intronic
Target gene
CACNA1E
miRNAs that regulate target gene
hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-1224-3p ; hsa-mir-4286 ; hsa-mir-605-5p ; hsa-mir-6815-3p ; hsa-mir-106b-3p ; hsa-mir-5587-3p ; hsa-mir-6840-5p ; hsa-mir-892b ; hsa-mir-541-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1359689; hsa-mir-1182/Downstream/10918249;
Nearest TSS
ENST00000473358/Upstream/21978; ENST00000609720/Downstream/14626;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/311954, chr1-CpG: 28/Downstream/278
Upstream sequence
ctagcatcacctggaagcttgttagaaatgcaaaatctcagtccttgccccagatcttctgagcctgcatctgcagtttaaccagatccccagaggtttg
Downstream sequence
tatgcacaaagtctgagatgtcctgGTCTAAATGTTCTTGACTCCTtaatctcttcaatccctttttccctgagtggatgtgaatactacagggagctcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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