Basic Information
VIS ID
TVIS44015576
Fusion event
HTLV-1-C1orf21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
184456150/184487016 (Hg38)
End
184456150/184487016 (Hg38)
Orient
-
Location type
Intronic
Target gene
C1orf21
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-146a-5p ; hsa-mir-7-5p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-93-3p ; hsa-mir-484 ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-552-5p ; hsa-mir-3065-5p ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-let-7a-5p ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-mir-98-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-202-3p ; hsa-mir-561-3p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-548at-5p ; hsa-mir-646 ; hsa-mir-708-3p ; hsa-mir-503-5p ; hsa-mir-136-3p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-5009-3p ; hsa-mir-186-3p ; hsa-mir-10a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/4048626; hsa-mir-1182/Downstream/8229312;
Nearest TSS
ENST00000473358/Upstream/99958; ENST00000489143/Downstream/52977;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/99526, chr1-CpG: 36/Downstream/177073
Upstream sequence
CTCCCTTGCCCCTTCAAGTGCTTGTATTGTCTGTAGCAGTGGAGACCTGCTGGGTGCTTCCTGGCCCTCTGGCACCATTCAGTGAAAGGTGAAAGGACTG
Downstream sequence
GAGCTGCAGGCAAGGCCTGCTTGGGGATGAGGGAAGTTCTCAAAACGTGCCTCAGTGACAAGAGAGGAAGTCAAAGGTTTCTTTACCTATTGCACTTCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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