Basic Information
VIS ID
TVIS44015578
Fusion event
HTLV-1-RNF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
185023415/185054283 (Hg38)
End
185023415/185054283 (Hg38)
Orient
+
Location type
Intronic
Target gene
RNF2
miRNAs that regulate target gene
hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-155-5p ; hsa-mir-186-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-92a-3p ; hsa-mir-149-5p ; hsa-mir-6504-5p ; hsa-mir-4284 ; hsa-mir-3064-5p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-7844-5p ; hsa-mir-3607-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p ; hsa-mir-548as-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-3613-3p
Nearest miRNA
hsa-mir-101-1/Upstream/4615893; hsa-mir-1182/Downstream/7662045;
Nearest TSS
ENST00000473358/Upstream/8187; ENST00000450350/Downstream/66586;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/8195, chr1-CpG: 73/Downstream/102435
Upstream sequence
TAGAGCTGCTAGGGCACGCAACGGGTTTCAATATGCCTTGGACTAAACTGGACATTATCATTCATTCTTTTTGCTAATCTGATGGCGGAAAACGAacccc
Downstream sequence
cagtttacaggtaaggaaatggcggcttaagttcagaactgttcacatacataaccggcaagtggcagagccgtgttttggcatcagaagcgactccgga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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