Basic Information
VIS ID
TVIS44015591
Fusion event
HTLV-1-DENND1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
197498468/197529338 (Hg38)
End
197498468/197529338 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
DENND1B
miRNAs that regulate target gene
hsa-mir-6869-5p ; hsa-mir-155-5p ; hsa-mir-4312 ; hsa-mir-532-5p ; hsa-mir-802 ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-195-3p
Nearest miRNA
hsa-mir-101-1/Upstream/946857; hsa-mir-1182/Downstream/1329535;
Nearest TSS
ENST00000473358/Upstream/81869; ENST00000440885/Downstream/17435;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/327749, chr1-CpG: 103/Downstream/245463
Upstream sequence
tatatgtgtgtgtgtgtgtgtgtgtgtgtgtatatgtatatatgtatatatatgtatatatgtgtatatatgtatatatatgtgtgtatatatatgtgtg
Downstream sequence
tgtgtgtgtgtgcacgcgcgcacatgtgtatgtgtgggtgggtgggtgtgtgtgtgcatatgcgtgtgCCAGGGTTTTAATAGGGCTTAACAACAAAAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate