Basic Information
VIS ID
TVIS44015596
Fusion event
HTLV-1-PPP1R12B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
202548083/202578955 (Hg38)
End
202548083/202578955 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPP1R12B
miRNAs that regulate target gene
hsa-mir-30b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-29a-5p ; hsa-mir-659-3p ; hsa-mir-92a-1-5p ; hsa-mir-1228-3p ; hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-188-5p ; hsa-mir-2114-3p ; hsa-mir-30b-3p ; hsa-mir-3160-3p ; hsa-mir-3192-5p ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4487 ; hsa-mir-455-3p ; hsa-mir-4661-3p ; hsa-mir-4728-5p ; hsa-mir-4780 ; hsa-mir-558 ; hsa-mir-6086 ; hsa-mir-6134 ; hsa-mir-623 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6780b-3p ; hsa-mir-6785-5p ; hsa-mir-6799-5p ; hsa-mir-6807-5p ; hsa-mir-6823-3p ; hsa-mir-6851-5p ; hsa-mir-6866-3p ; hsa-mir-6880-5p ; hsa-mir-6883-5p ; hsa-mir-7106-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-101-1/Upstream/575719; hsa-mir-1182/Downstream/2869347;
Nearest TSS
ENST00000473358/Upstream/4037; ENST00000428573/Downstream/25313;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/229887, chr1-CpG: 104/Downstream/63585
Upstream sequence
gacaaagacaatgctggaatttcagtttctaggcgtcaaacatttttggtgttttgttttccatcccacgtgtaataaaagaatgatctttggagtcagg
Downstream sequence
cacactgggattcaatattagctttgctgggtgccttgaactagttatggcacttttcatttccccatttgtagaaatcgggataacaactgtatcatag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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