Basic Information
VIS ID
TVIS44015603
Fusion event
HTLV-1-PINK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
20961463/20634970 (Hg38)
End
20961463/20634970 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
PINK1
miRNAs that regulate target gene
hsa-mir-27a-3p ; hsa-mir-27b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1182; hsa-mir-101-1/Downstream/353344;
Nearest TSS
ENST00000473358/Upstream/1515; ENST00000492302/Downstream/3159;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/912, chr1-CpG: 61/Downstream/26053
Upstream sequence
ggacacagctgttagggccaagcagtggctcctgggtttcctggtttccatcccagttcttattgctcatcaccactGTCTCATGTTTGAGCTCTGGCCA
Downstream sequence
GTTTGGGGTGACAGGTGACATCTGGCCTAGTCCCCAGCCCCTGACCTTGTCTTTTGCCACAGCTTAACTGGCAGAAGCTAAGGATGGGAAATTTGACTAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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