Basic Information
VIS ID
TVIS44015606
Fusion event
HTLV-1-EIF4G3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
21349467/21022974 (Hg38)
End
21349467/21022974 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
EIF4G3
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-24-3p ; hsa-mir-16-5p ; hsa-mir-221-3p ; hsa-mir-17-5p ; hsa-mir-3613-3p ; hsa-mir-543 ; hsa-mir-136-5p ; hsa-mir-377-5p ; hsa-mir-218-5p ; hsa-mir-548c-3p ; hsa-mir-4724-3p ; hsa-mir-6813-3p ; hsa-mir-3200-3p
Nearest miRNA
hsa-mir-12136/Upstream/34542; hsa-mir-101-1/Downstream/1243265;
Nearest TSS
ENST00000473358/Upstream/40529; ENST00000416959/Downstream/28020;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/235346, chr1-CpG: 77/Downstream/153648
Upstream sequence
TAAAGCTTCCCTGAATTACATGGTAAATGTTCTTTTACTATGAATAACAAGCTTTAAAGCAAAATCACTTTCAGTTTTCTTTCCTTCGAGGATGCTAATT
Downstream sequence
AGTAGTACCCTCAGTTAAAAACATTAGGCACGCAAAAACTTTTACTCACATTAGAATGAAAAAAACTCTCAAACTATACTTGACTTCAGATGTAGCAATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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