Basic Information
VIS ID
TVIS44015611
Fusion event
HTLV-1-USH2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
216375512/216202170 (Hg38)
End
216375512/216202170 (Hg38)
Orient
+
Location type
Intronic
Target gene
USH2A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-101-1/Upstream/4124485; hsa-mir-1182/Downstream/3915683;
Nearest TSS
ENST00000473358/Upstream/8119; ENST00000470448/Downstream/221226;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/634247, chr1-CpG: 43/Downstream/398827
Upstream sequence
AACAAAATTTGAAAAATCACTGAAGGCTAGAACAACGATGGAAAATAATTTAGCATGCCAAAAGCCAAAACCTAAAAGAAAAAAATAAATTTCAGTGCTG
Downstream sequence
AATATTCCAAAAGATTGTCTGGCATAAGCTTAAACTGGAAGTTGGAAGACTTATAACCTGATGACAATTAAAAGAAGTACAGTACTTGCTGAATGTTTGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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