Basic Information
VIS ID
TVIS44015630
Fusion event
HTLV-1-IL22RA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
24446495/24120005 (Hg38)
End
24446495/24120005 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA1A
Target gene
IL22RA1
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-12136/Upstream/190858; hsa-mir-101-1/Downstream/799340;
Nearest TSS
ENST00000473358/Upstream/7830; ENST00000439059/Downstream/23116;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/139478, chr1-CpG: 81/Downstream/67045
Upstream sequence
aggttctgggcactgatttcatttgtttgaagtcacacagcttgtgagtggtgaggctggaatttgagcccagatgggctgaacccaaggcAGAGCTTGC
Downstream sequence
AAAGTTGTGACATCAGTACAGTGTGTTATTGTACCCGTCCAGGGGCCACAGCCCTCACCTTCCTTTCAAACCCCATTCTCAGGATAGGGTCTGAAACTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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