Basic Information
VIS ID
TVIS44015642
Fusion event
HTLV-1-RCC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p35.3
Reference genome
GRCh37/hg19
Start
28864819/28538307 (Hg38)
End
28864819/28538307 (Hg38)
Orient
+
Location type
UTR3
Target gene
RCC1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-124-3p ; hsa-mir-941 ; hsa-mir-18a-3p ; hsa-mir-149-5p ; hsa-mir-92a-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-5692a ; hsa-mir-548c-3p ; hsa-mir-5190
Nearest miRNA
hsa-mir-12136/Upstream/1983714; hsa-mir-101-1/Downstream/2200849;
Nearest TSS
ENST00000473358/Upstream/2214; ENST00000411406/Downstream/14778;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/7508, chr1-CpG: 32/Downstream/14583
Upstream sequence
GGGGGGGATGGACAGGGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTG
Downstream sequence
GCCCTGGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAGTCATGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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