Basic Information
VIS ID
TVIS44015649
Fusion event
HTLV-1-ZNF362 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p35.1
Reference genome
GRCh37/hg19
Start
33759326/33293725 (Hg38)
End
33759326/33293725 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF362
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-6772-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-7106-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-4286 ; hsa-mir-3121-3p ; hsa-mir-335-3p ; hsa-mir-5696
Nearest miRNA
hsa-mir-12136/Upstream/1206718; hsa-mir-101-1/Downstream/38668;
Nearest TSS
ENST00000473358/Upstream/13375; ENST00000625117/Downstream/13623;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/16945, chr1-CpG: 78/Downstream/12820
Upstream sequence
TGTTCCTCAACAAATTAGGCAAACAAGGTGCAGGCCCAGCTGGCATTTCATTGCTCACCTGCTTGGTACAGCAGATTTGCCCAAACAGATGCTTGAAGAC
Downstream sequence
ACGCCCAGGGAGATGGTGCAAAGGCATGAGTGTGGAAAGCAGGGAAGGCCACTATTAGTGCATGCCAGGCTGCTGAGCTCCATTTGTGGACATCATCACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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