Basic Information
VIS ID
TVIS44015651
Fusion event
HTLV-1-CSMD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p35.1
Reference genome
GRCh37/hg19
Start
34127828/33662228 (Hg38)
End
34127828/33662228 (Hg38)
Orient
-
Location type
Intronic
Target gene
CSMD2
miRNAs that regulate target gene
hsa-mir-3941 ; hsa-mir-125b-2-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-495-5p ; hsa-mir-4650-5p ; hsa-mir-1972
Nearest miRNA
hsa-mir-12136/Upstream/329736; hsa-mir-101-1/Downstream/1007371;
Nearest TSS
ENST00000473358/Upstream/35644; ENST00000458277/Downstream/47276;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/28709, chr1-CpG: 160/Downstream/500954
Upstream sequence
TGGATGTTTGAGCATTGGCCATTTTGGGTAGCTCTTTGTCATGCTCCTCCATAATTGGCTATTGCAGTGCCTAATTAATTAAATTTAGATGACTCATGTT
Downstream sequence
CACTTCCAGTCTTTGCTGAGATCTGCACTCAACTAAGAACCTGAGCGTGCAGCATGTCCCATCAGCTTATTCATAACCATGCCCCAAGCCACCGTCTACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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