Basic Information
VIS ID
TVIS44015657
Fusion event
HTLV-1-MRPS15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
36926772/36461171 (Hg38)
End
36926772/36461171 (Hg38)
Orient
-
Location type
Intronic
Target gene
MRPS15
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-186-5p ; hsa-mir-4279 ; hsa-mir-6868-3p ; hsa-mir-6881-3p ; hsa-mir-6515-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-877-3p ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-10a-3p ; hsa-mir-7152-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6818-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-5088-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-3142 ; hsa-mir-1245b-5p ; hsa-mir-4695-5p
Nearest miRNA
hsa-mir-12136/Upstream/1791477; hsa-mir-101-1/Downstream/700392;
Nearest TSS
ENST00000473358/Upstream/1468; ENST00000641463/Downstream/3174;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/10448, chr1-CpG: 63/Downstream/2642
Upstream sequence
ggtatggtgggggaacaaaagtgtccctgccctgaagatgctctgtctagggatattgacaaatggaggcagaatgacagtgggctaagtgctgtgactg
Downstream sequence
gagaagcatgagatgcggggtgctaatcagggtagaagggagTCCCAGAGGAGAAGACTGCGGGAGGCTGAGGCTTGGCAGAGGCTGCTCACCTTGTTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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