Basic Information
VIS ID
TVIS44015662
Fusion event
HTLV-1-ATP6V0B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.1
Reference genome
GRCh37/hg19
Start
44441863/43976191 (Hg38)
End
44441863/43976191 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP6V0B
miRNAs that regulate target gene
hsa-mir-95-5p ; hsa-mir-634 ; hsa-mir-548t-5p ; hsa-mir-548t-3p ; hsa-mir-3609 ; hsa-mir-3942-5p ; hsa-mir-548aa ; hsa-mir-548ah-5p ; hsa-mir-4703-5p ; hsa-mir-548ap-3p ; hsa-mir-548az-5p ; hsa-mir-4433b-5p ; hsa-mir-4316 ; hsa-mir-4433a-5p ; hsa-mir-564 ; hsa-mir-3177-3p ; hsa-mir-1827 ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-3622a-5p ; hsa-mir-5692a ; hsa-mir-548n
Nearest miRNA
hsa-mir-12136/Upstream/137508; hsa-mir-101-1/Downstream/569302;
Nearest TSS
ENST00000473358/Upstream/136; ENST00000498543/Downstream/2752;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/607, chr1-CpG: 112/Downstream/2772
Upstream sequence
TCCTGACGGAGACTTCGCCCTTCATGTGGTCCAACCTGGGCATTGGCCTAGCTATCTCCCTGTCTGTGGTTGGGGCAGCCTGGTGAGTATTGGGGTGGTG
Downstream sequence
GGACTGGGGGCAGGGGCTGAGTCATGGCAGGTGGTGTCACTGGGGTCTTAGGCATGCTGAGGGCAGTGACAGCTTGGGCTCTGCTCATCAGTTTTTTATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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