Basic Information
VIS ID
TVIS44015665
Fusion event
HTLV-1-POMGNT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.1
Reference genome
GRCh37/hg19
Start
46655337/46189665 (Hg38)
End
46655337/46189665 (Hg38)
Orient
-
Location type
Intronic
Target gene
POMGNT1
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-330-5p ; hsa-mir-93-3p ; hsa-mir-222-3p ; hsa-mir-103a-3p ; hsa-mir-92a-3p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6803-5p ; hsa-mir-7109-5p ; hsa-mir-6751-5p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6835-5p ; hsa-mir-185-3p ; hsa-mir-4283 ; hsa-mir-4489 ; hsa-mir-7106-3p ; hsa-mir-4469 ; hsa-mir-3121-5p ; hsa-mir-6852-5p ; hsa-mir-5193 ; hsa-mir-1470 ; hsa-mir-660-3p ; hsa-mir-4667-3p
Nearest miRNA
hsa-mir-12136/Upstream/1644113; hsa-mir-101-1/Downstream/4870172;
Nearest TSS
ENST00000473358/Upstream/98; ENST00000371980/Downstream/1307;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/22405, chr1-CpG: 41/Downstream/13484
Upstream sequence
CACTAGTGAGGGTGGGATGGAGACAGAGACATGGGTCAGAGAGCTGTAGGGAGGGGTCACTGACGACCCTTTGGCCCAGCCCCCACCCCTCCTCAGAAAC
Downstream sequence
CACCTCAATTTGTAAGAGATAGCATCTTTTAGAATATGAATTTGGACAAGGAGGTTGGAAGAGGTGTTCTAAGAGTATAAAGAGGAGGTTCTGAGGTTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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