Basic Information
VIS ID
TVIS44015673
Fusion event
HTLV-1-ELAVL4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p33
Reference genome
GRCh37/hg19
Start
50646891/50181219 (Hg38)
End
50646891/50181219 (Hg38)
Orient
+
Location type
Intronic
Target gene
ELAVL4
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-141-3p ; hsa-mir-21-5p ; hsa-mir-510-3p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-340-5p ; hsa-mir-4635 ; hsa-mir-3163 ; hsa-mir-3121-3p ; hsa-mir-548c-3p ; hsa-mir-607 ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-643 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-488-5p ; hsa-mir-10b-3p
Nearest miRNA
hsa-mir-12136/Upstream/5635667; hsa-mir-101-1/Downstream/878618;
Nearest TSS
ENST00000473358/Upstream/4089; ENST00000642132/Downstream/41908;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/132571, chr1-CpG: 86/Downstream/151776
Upstream sequence
TAAGAAAAAATGTTCTAAAAATAACTCTCTGGCAGTAGGTCGTAAGTGTTGGAATGTCACACTGCCTGCTTGCTCAGCAACACGTGCATTCTGTGAGGGT
Downstream sequence
GTGTGGGTGTGTATTTGGCTCTGTGCACACATGGGTTATACTCTCTGGCATGGGAAGGAGAATAAAAAGCAAACAAATGAATTGTGTGTCTCCTCCAGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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