Basic Information
VIS ID
TVIS44015678
Fusion event
HTLV-1-TUT4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
52980522/52514850 (Hg38)
End
52980522/52514850 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
TUT4
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-let-7b-5p ; hsa-mir-26a-5p ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-203a-3p ; hsa-mir-216b-5p
Nearest miRNA
hsa-mir-12136/Upstream/678448; hsa-mir-101-1/Downstream/1539229;
Nearest TSS
ENST00000473358/Upstream/46360; ENST00000607321/Downstream/11080;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/110217, chr1-CpG: 115/Downstream/37736
Upstream sequence
TCTGTTTGTCAATAGTTTTATTTGTGAttttttttttttttttttgagatggagtcttgctctgtcgcccaggctggtgtgcagtggcacaatcttggct
Downstream sequence
caccgcaacctctgccccctgggttcaagcaattctcctgcctcagcctcccaagtagctgggactacaggtaccgactaccacacctcgctaatttttg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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