Basic Information
VIS ID
TVIS44015685
Fusion event
HTLV-1-FGGY integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.1
Reference genome
GRCh37/hg19
Start
60162389/59696717 (Hg38)
End
60162389/59696717 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
FGGY
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-12136/Upstream/4470994; hsa-mir-101-1/Downstream/36510;
Nearest TSS
ENST00000473358/Upstream/23031; ENST00000480847/Downstream/58955;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/399595, chr1-CpG: 90/Downstream/117698
Upstream sequence
AGGCCTTTCAATTGTTTTCTTTCTGTCTACCTACCTCACACTGTGTCCTTCATCTCTCTGTCTAGCCCCCAGGAAAAGTGCAGCAAGTGCAGGTATTTCT
Downstream sequence
GAAATGACGAGTGGCTCGCAAAAAGGATCTGATGAGTGTTAATAGTAAGCAATGTGTACCTAAGAGTGTAGACACTATTAGCATTTGGAAAAATAGGAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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