Basic Information
VIS ID
TVIS44015690
Fusion event
HTLV-1-RAVER2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
65244536/64778853 (Hg38)
End
65244536/64778853 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
RAVER2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-let-7a-5p ; hsa-mir-99a-5p ; hsa-mir-99b-5p ; hsa-mir-615-3p ; hsa-mir-149-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-197-3p ; hsa-mir-4684-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3124-3p ; hsa-mir-367-5p ; hsa-mir-1267
Nearest miRNA
hsa-mir-12132/Upstream/198930; hsa-mir-101-1/Downstream/278902;
Nearest TSS
ENST00000473358/Upstream/787; ENST00000470888/Downstream/62405;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/33298, chr1-CpG: 123/Downstream/186919
Upstream sequence
TGATCAATTAtttctctcttgtttctctccatttcttccttctccgttttcctttttaccgcactcccttcccatccacgctccttttcctcttacctct
Downstream sequence
gttgtttcctctcctcctttgcatcttttcttTAATCATACATTTGTTGATTTCCTAGTATTGCAGTAGAAATTTTGGAGTTGGAGtacatatctatata
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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