Basic Information
VIS ID
TVIS44015691
Fusion event
HTLV-1-AK4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
65675962/65210279 (Hg38)
End
65675962/65210279 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
AK4
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-3591-5p ; hsa-mir-4668-5p ; hsa-mir-3613-3p ; hsa-mir-665 ; hsa-mir-6821-5p ; hsa-mir-4650-3p ; hsa-mir-7160-5p ; hsa-mir-202-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-219b-3p ; hsa-mir-7162-3p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-5197-3p ; hsa-mir-3929 ; hsa-mir-5010-3p ; hsa-mir-592 ; hsa-mir-4711-3p ; hsa-mir-342-3p ; hsa-mir-4280 ; hsa-mir-4519 ; hsa-mir-3714 ; hsa-mir-6768-3p ; hsa-mir-4484 ; hsa-mir-548an ; hsa-mir-3686 ; hsa-mir-142-3p ; hsa-mir-3607-3p ; hsa-mir-95-5p
Nearest miRNA
hsa-mir-101-1/Upstream/151771; hsa-mir-11399/Downstream/1418161;
Nearest TSS
ENST00000473358/Upstream/44347; ENST00000483402/Downstream/37940;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/61064, chr1-CpG: 69/Downstream/44012
Upstream sequence
GTGAGAGAGAGCCCCTTTTCAGGACCTGTGACACAGCACCCCAAACTTTGGAGGCAGCCTTAGCCTATCCCCAGGGCCTCTGTGACCATTGCTGGGTCTA
Downstream sequence
GGACACCACACTCGCCCTGAAAGTGGCACTCTTTGAGGCCAGTCACTTCCAACTCTGCCTTTCATTTCTGAGAGGAAGGTAAGCCATCCTCCTGTTCTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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