Basic Information
VIS ID
TVIS44015701
Fusion event
HTLV-1-ST6GALNAC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
77368999/76903314 (Hg38)
End
77368999/76903314 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
ST6GALNAC5
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-5093 ; hsa-mir-3688-3p ; hsa-mir-377-3p
Nearest miRNA
hsa-mir-101-1/Upstream/5835598; hsa-mir-11399/Downstream/156829;
Nearest TSS
ENST00000473358/Upstream/35832; ENST00000488940/Downstream/92143;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/34465, chr1-CpG: 23/Downstream/315997
Upstream sequence
aaatgggcaaagaatctcaatagacgtatctccatagaaggcatacaaatagacaaagcacacggaaagattctcaacatcattagccatcaaagaaatg
Downstream sequence
caaatcaaaatcacaaggaaataactcttcacaccccgtaggatggctgtattgaaaaaaatataacaacaacttttgtcaaatgtggaaagaaattaga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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