Basic Information
VIS ID
TVIS44015709
Fusion event
HTLV-1-HFM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
91786332/91320775 (Hg38)
End
91786332/91320775 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
HFM1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-218-5p ; hsa-mir-2681-5p ; hsa-mir-4724-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-551b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/4963088; hsa-mir-11399/Downstream/2526057;
Nearest TSS
ENST00000473358/Upstream/298503; ENST00000497611/Downstream/8162;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/298525, chr1-CpG: 62/Downstream/83544
Upstream sequence
GGAAGGACAGGGATTTAAGCTAGTAGGTACAGAACCATGGCAGGGCTCTCTGTTTCTCTGCACCAGATAAGGCAAGCAGTGATGTCCTATGATCTTACCC
Downstream sequence
CTGAGCTTGTCCTCAGTAAAAACAGAAGTGCCACAGCCTCAGGTGAGGTGGCAGCTCTACCACCTCAACTAACAGGGGCAGAGTTACATGGTAGTTATGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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