Basic Information
VIS ID
TVIS44015720
Fusion event
HTLV-1-PLPPR5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
99370431/98904875 (Hg38)
End
99370431/98904875 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1M
Target gene
PLPPR5
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/858704; hsa-mir-11399/Downstream/1376366;
Nearest TSS
ENST00000473358/Upstream/242652; ENST00000425113/Downstream/99401;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/242720, chr1-CpG: 74/Downstream/99501
Upstream sequence
CTGTTAATTACAAAGGAGAGGTATCCGTGAAGAAAGAACAGGGAAAGGCCATAGATGAAGGATCAGCATATACTATGGGTAGGGGAGAGGGATGGTTTTC
Downstream sequence
TTAGTGACACTCTGGCTGGGAGCCCTTTTCTACTGTAAATCATGAGGTGAGATAAGTCCTCTAAATCAGCACCTAACAGCAGACTTTGCCAAATGACATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate