Basic Information
VIS ID
TVIS44015730
Fusion event
HTLV-1-HPCAL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
10527431/10387305 (Hg38)
End
10527431/10387305 (Hg38)
Orient
-
Location type
Intronic
Target gene
HPCAL1
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-3976 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4745-3p ; hsa-mir-1538 ; hsa-mir-873-5p ; hsa-mir-6746-5p ; hsa-mir-6784-5p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-4747-3p ; hsa-mir-6165 ; hsa-mir-2278 ; hsa-mir-1249-5p ; hsa-mir-125a-3p ; hsa-mir-1321 ; hsa-mir-3197 ; hsa-mir-3934-5p ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4779 ; hsa-mir-5587-5p ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6797-5p ; hsa-mir-6801-5p ; hsa-mir-6880-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-764 ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-4261/Upstream/194634; hsa-mir-10b/Downstream/1153300;
Nearest TSS
ENST00000437798/Upstream/18541; ENST00000422133/Downstream/32716;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/82922, chr2-CpG: 54/Downstream/32285
Upstream sequence
AGTCCAAAGAGTAGTCGCGTGTGAATCCACCTCCTTGTGCCAGCCTCACGGCCTCCTCAGGAAGGGCATGGAGGAGCAGTGGGATGCCCACGGTACCGTG
Downstream sequence
GAGGAAGCAGTCCTGGAGGAAGGGTGACTGGCCGAGGGCCATGCGGTGACGCACTGGGGACTGGCTCTAGCTGCTGTGGGGCACGTCCACGTGGAGAAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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