Basic Information
VIS ID
TVIS44015752
Fusion event
HTLV-1-STEAP3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
120022420/119264844 (Hg38)
End
120022420/119264844 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA2S
Target gene
STEAP3
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-7109-5p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-92a-1-5p ; hsa-mir-6848-5p ; hsa-mir-6846-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-4283 ; hsa-mir-4437 ; hsa-mir-24-3p ; hsa-mir-296-3p ; hsa-mir-8057 ; hsa-mir-3978 ; hsa-mir-1299 ; hsa-mir-760 ; hsa-mir-6822-3p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-7854-3p ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-518c-5p ; hsa-mir-5197-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/5543476; hsa-mir-10b/Downstream/8158693;
Nearest TSS
ENST00000437798/Upstream/15773; ENST00000492375/Downstream/101838;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1450, chr2-CpG: 85/Downstream/101821
Upstream sequence
AAGAGAGTAGGGCCAGTGAAGGCTGCCCAGAGAGAATGTCACAGATGAGGCTGCCCCTGCCCCCCCCCCGCCAGGGAGGTTTCATGAGCTCATGTCTATG
Downstream sequence
CAGCACATAAGGGTTCTTCAGTGAAAAGCAGGAGAAGAGCCCACTGCAAGGATAGCTCATTAGGCACATGACCGATGCAGGGAAGGCCATGCCGGGGAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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