Basic Information
VIS ID
TVIS44015762
Fusion event
HTLV-1-AMER3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
131518449/130760876 (Hg38)
End
131518449/130760876 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
AMER3
miRNAs that regulate target gene
hsa-mir-7703 ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-1227-3p ; hsa-mir-4252 ; hsa-mir-6889-3p ; hsa-mir-4793-3p ; hsa-mir-2116-3p ; hsa-mir-1224-3p ; hsa-mir-1273g-3p ; hsa-mir-6807-5p ; hsa-mir-6499-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/3337258; hsa-mir-10b/Downstream/730284;
Nearest TSS
ENST00000437798/Upstream/4585; ENST00000526381/Downstream/76040;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/4266, chr2-CpG: 93/Downstream/36647
Upstream sequence
AGGTCTCCACAACACACCCCAAGGCAGCATGTTTAAAAACTAAACCCTAGCTCTTCTTTCACCTTGGCTCAGCTCCCTCCTCCTTCGCTCATTTCCCTCC
Downstream sequence
TCGAGCTGTCCCACGCTGTTGGTGTAGATCCAAGCCTTGGCCTTCAGAACTCCCTGCCTGCTTCTCTATCCCTGCTGTCGGTGAGCCCTGGCATTCTTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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