Basic Information
VIS ID
TVIS44015763
Fusion event
HTLV-1-ARHGEF4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
131794747/131037174 (Hg38)
End
131794747/131037174 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
ARHGEF4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4761-5p ; hsa-mir-4693-3p ; hsa-mir-6507-5p ; hsa-mir-513b-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/3613556; hsa-mir-10b/Downstream/453986;
Nearest TSS
ENST00000437798/Upstream/1689; ENST00000527365/Downstream/2355;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1558, chr2-CpG: 83/Downstream/2615
Upstream sequence
TGCTGCCCCCAGGAATAACCCAGGGCTCTGTGCCTGGGACCCCGTGGAGGCCTCTGGAGGTCTGCAGCCCCCGCGTGGCTGCCGCGCTGTGAGGGTTCCT
Downstream sequence
GGGCTCACAGGCTCATGTGTCACTCTGAGGAGAGCGTCCATCAGGACTGGAGCAGGTTTTACCCCCAGGAAAGAGAAGGTTTGTCCTTCCCTGAACTTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate