Basic Information
VIS ID
TVIS44015774
Fusion event
HTLV-1-LRP1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
141076850/140319281 (Hg38)
End
141076850/140319281 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LRP1B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-200c-3p ; hsa-mir-106b-3p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-128-1/Upstream/4653803; hsa-mir-10b/Downstream/267345;
Nearest TSS
ENST00000437798/Upstream/21312; ENST00000410015/Downstream/38787;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1538201, chr2-CpG: 58/Downstream/1810874
Nearest cancer related gene
LRP1B(TSG, No orient, 0)
Upstream sequence
GTGGAAACATGGGATTACACAGAAGAGGATTACATAAAAGAGGAAAGGAAAACCACCAAAAACTGTCTGAAACTTGACTCTAAACAATACTTGTAACATC
Downstream sequence
AGAGCCAATGTAAAAGTCACTTGGTAGCATTATTAGTTTATTTCTGTGCATTATCCTAATCTCTCTCCTAAATGCCTCTCTCACCCAAATTTTCTAAGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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