Basic Information
VIS ID
TVIS44015776
Fusion event
HTLV-1-ARHGAP15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
143867111/143109542 (Hg38)
End
143867111/143109542 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
ARHGAP15
miRNAs that regulate target gene
hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-6807-5p ; hsa-mir-4698 ; hsa-mir-586 ; hsa-mir-5700 ; hsa-mir-3662 ; hsa-mir-4764-3p ; hsa-mir-3134 ; hsa-mir-4495 ; hsa-mir-1246 ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-8087 ; hsa-mir-6750-3p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-128-1/Upstream/2522857; hsa-mir-10b/Downstream/6220736;
Nearest TSS
ENST00000437798/Upstream/18180; ENST00000460776/Downstream/19772;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/978558, chr2-CpG: 111/Downstream/827221
Nearby gene
ARHGAP15(+19788) ;
Upstream sequence
ttctctcttcccaccatgacatacattcccttataatgacctggaaaactagattcaaagttaaaattcttatgctttttagagtccaccctgaaatgcg
Downstream sequence
ggtgcaggagaacagagccccttgcccctggttctcagtttgagtcctggtttatttcccaccttgggctccatcccacagctcaagggattcactgaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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