Basic Information
VIS ID
TVIS44015781
Fusion event
HTLV-1-ARL5A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
152675736/151819222 (Hg38)
End
152675736/151819222 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
ARL5A
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-202-3p ; hsa-mir-455-3p ; hsa-mir-7977 ; hsa-mir-1294 ; hsa-mir-4316 ; hsa-mir-3188 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-3975 ; hsa-mir-2467-5p ; hsa-mir-5690 ; hsa-mir-17-3p ; hsa-mir-5588-3p ; hsa-mir-1254 ; hsa-mir-1273g-3p ; hsa-mir-1292-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3116 ; hsa-mir-3609 ; hsa-mir-3612 ; hsa-mir-3690 ; hsa-mir-377-5p ; hsa-mir-4252 ; hsa-mir-4257 ; hsa-mir-4537 ; hsa-mir-4695-5p ; hsa-mir-4793-3p ; hsa-mir-508-5p ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-548ah-5p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6512-3p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6720-5p ; hsa-mir-6840-3p ; hsa-mir-6849-3p ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-873-3p
Nearest miRNA
hsa-mir-128-1/Upstream/450811; hsa-mir-10b/Downstream/7367613;
Nearest TSS
ENST00000437798/Upstream/27136; ENST00000420365/Downstream/9219;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/408450, chr2-CpG: 64/Downstream/8739
Upstream sequence
TATATAACAATAAAGAATGACTAAAAAATGTGTATATGTATAAATAATGTACACAGAGACAACGAAGTAAAAAACAGTACTCTCTCAGTTTCTTACAAGG
Downstream sequence
GCCgtaatcagctaaggaggttaaacacttattccaaccatgttaccattttttcaaaatagtttgctacggttcttttataattgctttcagagcctga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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