Basic Information
VIS ID
TVIS44015782
Fusion event
HTLV-1-CACNB4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
152752518/151896004 (Hg38)
End
152752518/151896004 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CACNB4
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-128-1/Upstream/527593; hsa-mir-10b/Downstream/7290831;
Nearest TSS
ENST00000437798/Upstream/11838; ENST00000420365/Downstream/75744;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/67387, chr2-CpG: 108/Downstream/202115
Upstream sequence
ggcaatctcagctcacatgctcctctgcctcctgggttcaagcaattctcctgcatcagcctccccagtagttggaattataggtgcatgccatgatatc
Downstream sequence
cagctaattttttgtattttttgtagagacggggtttcaccatgttggccggggctgctctgaactcctgacctcaggtgattcgcctgccttggcctcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate